Possible Linkage of SP6 Transcriptional Activity with Amelogenesis by Protein Stabilization

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Possible Linkage of SP6 Transcriptional Activity with Amelogenesis by Protein Stabilization

Ameloblasts produce enamel matrix proteins such as amelogenin, ameloblastin, and amelotin during tooth development. The molecular mechanisms of ameloblast differentiation (amelogenesis) are currently not well understood. SP6 is a transcription factor of the Sp/KLF family that was recently found to regulate cell proliferation in a cell-type-specific manner. Sp6-deficient mice demonstrate charact...

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Novel genetic linkage of rat Sp6 mutation to Amelogenesis imperfecta

BACKGROUND Amelogenesis imperfecta (AI) is an inherited disorder characterized by abnormal formation of tooth enamel. Although several genes responsible for AI have been reported, not all causative genes for human AI have been identified to date. AMI rat has been reported as an autosomal recessive mutant with hypoplastic AI isolated from a colony of stroke-prone spontaneously hypertensive rat s...

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Differential modulation of transcriptional activity of oestrogen receptors by direct protein-protein interactions with retinoid receptors.

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Effects of saturation mutagenesis of the phage SP6 promoter on transcription activity, presented by activity logos.

A full set of SP6 promoter variants with all possible single substitutions at positions -17 to +5 was constructed. Transcription activities of these variants were individually measured in vivo and in vitro to determine the contribution of each base pair to the promoter activity. The in vivo activity was measured indirectly by transcriptional interference of the replication of promoter-bearing p...

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ژورنال

عنوان ژورنال: Journal of Biomedicine and Biotechnology

سال: 2011

ISSN: 1110-7243,1110-7251

DOI: 10.1155/2011/320987